Warfarin Pregnancy: see this medicine in the DysNet teratogen register
ATC B01AA03 · WHO DDD 7.5 mg (oral) · 5 mg tablet
Class: Antithrombotic agents. ATC code B01AA03 stands for "warfarin" in the WHO index, whose DDD is 7.5 mg by the oral route [1].
WHO Model List of Essential Medicines 2025: listed, core list, also on the children’s list [2].
Indications on the WHO list (4)
- Venous thromboembolism · core list · children’s list · 10. Medicines affecting the blood 10.2. Medicines affecting coagulation · first added 1977
- Cerebral ischaemic stroke due to embolic occlusion · core list · children’s list · 10. Medicines affecting the blood 10.2. Medicines affecting coagulation · first added 1977
- Atrial fibrillation · core list · children’s list · 10. Medicines affecting the blood 10.2. Medicines affecting coagulation · first added 1977
- Other specified diseases of arteries or arterioles · core list · children’s list · 10. Medicines affecting the blood 10.2. Medicines affecting coagulation · first added 1977
The WHO electronic list states that the 2025 PDF lists are binding: adults’ list, children’s list.
| Country | Packs | Kind of figure | Cost per DDD | Annual cost at the WHO standard dose |
|---|---|---|---|---|
| France | 2 | List price | €0.29 to €0.31 | €107.49 to €112.05 |
| Spain | 1 | List price | €0.16 | €59.68 |
| United Kingdom | 1 | Reimbursement tariff | €0.05 | €19.84 £16.82 |
Names, authorisations and literature
Trade names (10)
- France (1)
- COUMADINE [4]
- Spain (1)
- ALDOCUMAR [5]
- Italy (1)
- COUMADIN [6]
- United States (2)
- Coumadin, Jantoven [6]
- United States, discontinued (3)
- Athrombin, Athrombin-K, Panwarfin [6]
- Canada (2)
- APO-WARFARIN, TARO-WARFARIN [6]
- In other languages
- warfarine (French); warfarina (Spanish); Warfarine (Dutch); Varfarina (Portuguese); warfarinum (Latin) [6]
Links lead to the official product page: the EPAR for the European Union, the public medicines database for France, the CIMA summary of product characteristics for Spain, the dm+d for the United Kingdom. An asterisk marks a name taken from the DysNet register only.
European public assessment reports, EPAR (0)
The European Medicines Agency's list holds no medicine with ATC code B01AA03: this medicine has no EPAR [7].
Literature (PubMed, 36,756 papers)
PubMed counts 36,756 papers on this medicine [8]. The selection gives the most recent of each type; the Method page says how it is made. See the search in PubMed ↗
Cochrane reviews (70)
- Kozieł-Siołkowska M, et al. Antiplatelet versus anticoagulation treatment for people with heart failure in sinus rhythm. Cochrane Database Syst Rev. 2025. PubMed 40497467 ↗ doi ↗
- Chen B, et al. Interrupted versus uninterrupted anticoagulation for cardiac rhythm management device insertion. Cochrane Database Syst Rev. 2025. PubMed 39873294 ↗ doi ↗
- Clezar CN, et al. Pharmacological interventions for asymptomatic carotid stenosis. Cochrane Database Syst Rev. 2023. PubMed 37565307 ↗ doi ↗
- Shantsila E, et al. Antiplatelet agents and anticoagulants for hypertension. Cochrane Database Syst Rev. 2022. PubMed 35900898 ↗ doi ↗
- Mohamed I, et al. Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts. Cochrane Database Syst Rev. 2021. PubMed 34298589 ↗ doi ↗
Systematic reviews and meta-analyses (1,202)
- Piyabun-Yanon C, et al. Prothrombin complex concentrate (PCC) vs. non-PCC strategies for warfarin reversal in left ventricular assist device recipients: A systematic review and meta-analysis. Intensive Crit Care Nurs. 2026. PubMed 42667788 ↗ doi ↗
- Søndergaard C, et al. Calciphylaxis in chronic kidney disease: a systematic review of pathomechanisms and risk factors for calcific uremic arteriolopathy. Ren Fail. 2026. PubMed 42572798 ↗ doi ↗
- Wu X, et al. Comparative efficacy and safety of apixaban and rivaroxaban versus warfarin in atrial fibrillation patients with end-stage renal disease: a systematic review and meta-analysis. Ren Fail. 2026. PubMed 42128628 ↗ doi ↗
- Yasuda N, et al. Clinical significance of CT-detected hypoattenuated leaflet thickening after transcatheter aortic valve replacement: A systematic review and meta-analysis. J Cardiovasc Comput Tomogr. 2026. PubMed 42816231 ↗ doi ↗
- Yamamoto J, et al. Major bleeding modifiers in anticoagulated patients with atrial fibrillation and heart failure: a systematic review. J Thromb Thrombolysis. 2026. PubMed 42791448 ↗ doi ↗
Practice guidelines (99)
- Dong NG, et al. Expert Consensus on Clinical Application of Implantable Biventricular Assist Devices. Curr Med Sci. 2025. PubMed 40643876 ↗ doi ↗
- Tran HA, et al. 2025 Guidelines for direct oral anticoagulants: a practical guidance on the prescription, laboratory testing, peri-operative and bleeding management. Intern Med J. 2025. PubMed 40448969 ↗ doi ↗
Names and identifiers
- INN
- warfarin source ↗
- CAS
- 81-81-2
- ATC
- B01AA03 (systemic)
- SNOMED CT
- 372756006, 41509001, 48603004, 63167009
- RxNorm
- 11289 ↗
- Wikidata
- Q113368879 ↗
- Wikipedia
- en.wikipedia.org/wiki/Warfarin ↗
Names and identifiers taken from the DysNet register [6].
Health technology assessments (2)
The opinions of the assessment bodies of the pilot countries and of Germany, with a link to each opinion. The status shown is the one each body publishes.
France, HAS Transparency Committee (2)
SMR: actual clinical benefit. ASMR: improvement in actual clinical benefit, from I (major) to V (none). Opinions taken from the BDPM [4].
- CT-16065 · 24 January 2018 · Réévaluation SMR et ASMR · SMR Important · ASMR V · COUMADINE
Wording of the opinion, in French
SMR : Le service médical rendu par COUMADINE reste important : • en prévention des complications thromboemboliques en rapport avec une FANV, • dans le traitement des TVP et EP et la prévention de leurs récidives, en relais de l’héparine.
ASMR : Au regard des données disponibles, la Commission considère que COUMADINE n’apporte pas d’amélioration du service médical rendu (ASMR V) : • dans la stratégie thérapeutique de prévention des complications thromboemboliques en rapport avec la FANV qui comprend les AVK et les anticoagulants non-AVK, • dans la stratégie thérapeutique de traitement de la thrombose veineuse profonde (TVP) et de l’embolie pulmonaire (EP) et la prévention de la récidive de TVP et d’EP chez l’adulte, qui comprend les AVK et les anticoagulants oraux non-AVK.
- CT-10032 · 1 February 2012 · Renouvellement d'inscription (CT) · SMR Important · COUMADINE
Wording of the opinion, in French
SMR : Le service médical rendu par ces spécialités reste important dans les indications de l'AMM.
England, NICE (0)
NICE has published no technology appraisal that names this medicine among the technologies appraised [9].
Scotland, SMC (0)
The Scottish Medicines Consortium has published no advice on this medicine [10].
Germany, G-BA (0)
The G-BA has run no early benefit assessment (AMNOG) of this medicine on its own [11].
Spain, AEMPS therapeutic positioning reports (0)
The AEMPS database of therapeutic positioning reports holds no report on this medicine [12].
How the figure is computed
Example, France: the pack COUMADINE 5 mg, comprimé sécable, plaquette(s) thermoformée(s) PVC-aluminium de 30 comprimé(s), costs €5.89. It holds 150 mg, which is 20 DDD. The cost per DDD is €5.89 ÷ 20 = €0.29, and the annual cost at the WHO standard dose, list price, is that cost × 365 = €107.49.
France
Public price in France, including VAT and the per-pack dispensing fee. Source [4], read on 9 October 2026. ATC match: through the active substance (BDPM substance code), since the BDPM gives no ATC code.
Show the 2 packs
| Product | Pack | Price | DDD per pack | Cost per DDD | Annual cost at the WHO standard dose | Source line |
|---|---|---|---|---|---|---|
| COUMADINE 5 mg, comprimé sécableTEOFARMA | plaquette(s) thermoformée(s) PVC-aluminium de 30 comprimé(s) | €5.89 | 20 | €0.29 | €107.49 | CIS 63245753 / CIP13 3400935693099substance code 00678 (WARFARINE SODIQUE) in CIS_COMPO_bdpm |
| COUMADINE 5 mg, comprimé sécableDIFARMED (ESPAGNE) | plaquette(s) thermoformée(s) de 30 comprimé(s) | €6.14 | 20 | €0.31 | €112.05 | CIS 68364117 / CIP13 3400949002313substance code 00678 (WARFARINE SODIQUE) in CIS_COMPO_bdpm |
Spain
Retail price including VAT (PVP IVA). Source [13][5], read on 9 October 2026. ATC match: ATC code of each national code, checked in CIMA.
Show the 1 pack
| Product | Pack | Price | DDD per pack | Cost per DDD | Annual cost at the WHO standard dose | Source line |
|---|---|---|---|---|---|---|
| ALDOCUMAR 5MG 40 COMPRIMIDOSALDO-UNION, S.L. | 40 COMPRIMIDOS | €4.36 | 26.67 | €0.16 | €59.68 | Código Nacional 870428AEMPS CIMA, registration 63064 |
United Kingdom
Drug Tariff basic price paid to the pharmacy, excluding VAT (Part VIIIA Category M). Source [14][15], read on 9 October 2026. ATC match: ATC code of the virtual product (VMP) in the dm+d.
Show the 1 pack
| Product | Pack | Price | DDD per pack | Cost per DDD | Annual cost at the WHO standard dose | Source line |
|---|---|---|---|---|---|---|
| Warfarin 5mg tablets | 28 tablet | £0.86 | 18.67 | £0.05 | £16.82€19.84 | VMPP SNOMED 1170211000001106dm+d browser, VMP 316 |
References
- WHO Collaborating Centre for Drug Statistics Methodology. ATC/DDD Index 2026 [Internet]. Oslo: Norwegian Institute of Public Health; [updated 2026 Jan 20; cited 2026 Oct 9]. Available from: https://atcddd.fhi.no/atc_ddd_index/
- World Health Organization. Electronic Essential Medicines List (eEML) [Internet]. Geneva: WHO; [cited 2026 Oct 9]. Available from: https://list.essentialmeds.org/
- European Central Bank. Euro foreign exchange reference rates, 9 October 2026 [Internet]. Frankfurt am Main: ECB; 2026 [cited 2026 Oct 9]. Available from: https://www.ecb.europa.eu/stats/policy_and_exchange_rates/euro_reference_exchange_rates/html/index.en.html
- Base de données publique des médicaments [Internet]. Paris: Ministère du Travail, de la Santé, des Solidarités et des Familles; 2026 [updated 2026 Oct 8; cited 2026 Oct 9]. Available from: https://base-donnees-publique.medicaments.gouv.fr/telechargement
- Agencia Española de Medicamentos y Productos Sanitarios. CIMA: Centro de información de medicamentos [Internet]. Madrid: AEMPS; [cited 2026 Oct 9]. Available from: https://cima.aemps.es/cima/
- DysNet, the dysmelia network. Teratogen register [Internet]. [place unknown]: DysNet; 2026 [updated 2026 Sep 12; cited 2026 Oct 9]. Available from: https://www.dysnet.org/knowledge/teratogens/
- European Medicines Agency. Download medicine data [Internet]. Amsterdam: EMA; 2026 [updated 2026 Oct 9; cited 2026 Oct 9]. Available from: https://www.ema.europa.eu/en/medicines/download-medicine-data
- PubMed [Internet]. Bethesda (MD): National Library of Medicine (US); [cited 2026 Oct 9]. Available from: https://pubmed.ncbi.nlm.nih.gov/
- National Institute for Health and Care Excellence. Technology appraisal guidance [Internet]. London: NICE; [cited 2026 Oct 9]. Available from: https://www.nice.org.uk/guidance/published?ngt=Technology%20appraisal%20guidance
- Scottish Medicines Consortium. Medicines advice [Internet]. Glasgow: SMC; [cited 2026 Oct 9]. Available from: https://scottishmedicines.org.uk/medicines-advice/
- Gemeinsamer Bundesausschuss. Nutzenbewertung nach § 35a SGB V: Apixaban [Internet]. Berlin: G-BA; [cited 2026 Oct 9]. Available from: https://www.g-ba.de/bewertungsverfahren/nutzenbewertung/
- Agencia Española de Medicamentos y Productos Sanitarios. Informes de posicionamiento terapéutico [Internet]. Madrid: AEMPS; [cited 2026 Oct 9]. Available from: https://www.aemps.gob.es/medicamentos-de-uso-humano/evaluacion-de-tecnologias-sanitarias/informes-de-posicionamiento-terapeutico/
- Ministerio de Sanidad. Nomenclátor de facturación de octubre 2026 [Internet]. Madrid: Ministerio de Sanidad; 2026 [cited 2026 Oct 9]. Available from: https://www.sanidad.gob.es/profesionales/nomenclator.do
- NHS Business Services Authority. Drug Tariff Part VIIIA, October 2026 [Internet]. Newcastle upon Tyne: NHSBSA; 2026 [cited 2026 Oct 9]. Available from: https://www.nhsbsa.nhs.uk/pharmacies-gp-practices-and-appliance-contractors/drug-tariff/drug-tariff-part-viii
- NHS Business Services Authority. dm+d browser: NHS dictionary of medicines and devices [Internet]. Newcastle upon Tyne: NHSBSA; [updated 2026 Oct 1; cited 2026 Oct 9]. Available from: https://dmd-browser.nhsbsa.nhs.uk/